Ibutamoren is frequently used to increase lean body mass i.e. create bigger muscles. As previously mentioned, ibutamoren increases growth hormone levels and IGF-1. Both growth hormone and IGF-1, in turn, increase muscle mass, muscle strength, and reduce body fat. In 24 obese men, a two-month treatment (DB-RCT) with Ibutamoren increased lean mass, and transiently increased basal metabolic rate (BMR).
In a study (DB-RCT) in eight food-deprived healthy volunteers, MK-677 reversed diet-induced protein loss, that could cause muscle wasting. In 123 elderly patients with hip fractures, ibutamoren improved gait speed, muscle strength and reduced the number of falls (RCT).
Growth hormone increases tissue regeneration and wound healing, so MK-677 may help with these.
YK-11 acts as a potent Myostatin inhibitor in the body, allowing for muscular development far exceeding one’s genetic potential. Myostatin acts as a regulator of skeletal muscle mass, limiting how much muscle the body can grow. He attaches itself to the androgen receptor, and induces the muscle cells to produce more Follistatin, consequently inhibiting Myostatin in the body, which then results in more overall muscle growth YK-11 attaches itself to an androgen receptor. This prompts muscle cells to produce more anabolic factors that in turn leads to increased muscle growth. In a past study, the effect of this compound on muscle cells was proven to be much higher. In this study, it was found that the muscle cells produced more anabolic compounds when exposed to 500 nmol of this compound than when exposed to testosterone.
YK-11 just like any other SARM is designed to help with muscle growth. It has been proven that the compound promotes muscle growth, muscle retention, and the growth of new muscle cells. Its side effects are minimal and cannot be compared to the side effects of steroids available in the market. This possibly explains why it is receiving a lot of attention as many are looking for a solution that is safe and works to enhance muscle growth.
This compound works great for those looking to build muscle mass. The compound is also ideal for people who want to maintain the amount and quality of their muscles and keep fat cells at bay.
The chemical structure of YK-11 is quite similar to that of steroids. It is derived from testosterone as a synthetic steroid. This does NOT mean that the compound is a steroid. Actually, it is classified as a SARM or Selective Androgen Receptor Modulator in FULL. Given that this is an androgen receptor, it delivers the same results as other androgens receptors.
Unlike other SARMs, this compound comes with a steroid backbone. This possibly explains why it is more effective and is classified among the most potent SARMs. It, however, comes without the adverse side effects associated with steroids.
LGD-4033, also called Ligandrol or Anabolicum, was developed by the pharmaceutical Ligand (hence the name), with the goal in mind to promote healing properties in the body as well as stimulating positive activity in bones and muscles. He’s one of the better-studied SARMs. It’s been through multiple human trials, with interesting results. From these trials, the results have shown increases in lean body mass and decreases in body fat. There is also a significant increase in strength, well-being, as well as healing possibilities.
In studies, healthy men who took LGD-4033 for 21 days saw a significant increase in lean body mass. One milligram per day was enough to cause significant muscle growth. The higher the dose, the more muscle participants put on. In another trial, participants took doses as high as 22 mg/day with no side effects or safety issues.
In studies with rats, LGD-4033 increases bone density, muscle mass, and sex drive, without damaging prostate or liver tissue.
LGD-4033 does stimulate fat loss, so it will make you more muscular and leaner. It also stimulates the central nervous system (CNS) so it helps increase strength and performance.
RAD-140 builds muscle and burns fat. With multiple published human trials under its belt, RAD-140 (also called Testolone) is one of the best-studied SARMs. Those studies found powerful results, too. Testolone shows no meaningful side effects and is very effective at building muscle.
Users have said they lost body fat on Testolone (RAD140) and this is due to an increase in metabolism. When you increase lean muscle mass, you also will have an easier time losing body fat.
Testolone treatment has been clinically shown to suppress cancer cell growth by blocking the effects of estrogen on tissues. Specifically, RAD140 prevents the production of a protein called ESR1, which is implicated in the development of cancer.
RAD-140 has greater anabolic effect than testosterone. Elderly men and women who took modest doses of Testolone for 12 weeks grew 3 pounds of muscle and lost a pound of fat, with no changes to diet or exercise. Cancer patients saw nearly identical results along with a similar timeframe. There were no side effects in either study. A pound of muscle a month is about what you would expect with a solid workout routine – but the people taking Testolone in these studies weren’t exercising. Combining the two would be even more powerful, in theory. Pretty impressive!
- RAD-140: 2-chloro-4-[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino-3-methylbenzonitrile,organic MCT oil, natural lemon flavour with stevia.
- MK-677: R)-1’-(2-methylalanyl-O-benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4’-piperidine], organic MCT oil, natural lemon flavor with stevia.
- LGD-4033: 2-chloro-4-[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino-3-methylbenzonitrile,organic MCT oil, natural lemon flavour with stevia.
- YK-11: (17-alpha,20E) 17,20-[(1-methoxyethylidene)bis(oxy)] 3-oxo-19-norpregna-4,20-diene 21-carboxylic acid methyl ester,organic MCT oil, natural lemon flavour with stevia.
For research only.